How White Blood Cells Clear Malaria Infection, and How This Alters the Immune Response

Grant number: 628611 | Funding period: 2010 - 2012

Completed

Abstract

Macrophage white blood cells clear malaria infected cells by eating them, by three routes- by recognising ANTIBODIES or COMPLEMENT on the cell surface, or by the cell BINDING directly to the macrophage. Each has different results, such as amounts of cytokines produced. Cytokines clear malaria; in excess they can cause fatal immune pathology. We will investigate how variations in amount of antibody and complement and route of uptake of malaria infected cells might determine malaria outcome.

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University of Melbourne Researchers

Stephen Rogerson